The First HIV/AIDS Generation Reaches Retirement Age

Newsweek published an article by Erika Hayasaki on September 18, 2014, "The First HIV/AIDS Generation Reaches Retirement Age".  The article covers many of the issues of an aging HIV infected population.  These issues are the impetus of HNRP research focusing on prospective memory, adherence to medication, comorbid aging conditions such as diabetes and cardiovascular disease, and neurological conditions such as dementia.

Click Here to link to the full article.



Newly Funded Grant - Endocannabinoids, Cannabis, and Neurocognitive Deficits in HIV

Dr. Brook Henry received notice of funding for his study that will examine dose response interaction between cannabis use and the endocannabinoid (EC) system.

Previous studies have indicated that the anti-inflammatory and neuroprotective properties of the EC system may have therapeutic utility in reducing HIV-induced damage to the central nervous system, including preventing the development of HIV-associated neurocognitive disorders (HAND).  In contrast, cannabis use is reported to induce neurocognitive and functional impairment after chronic exposure.


CHARTER Manuscript Highlighted in Neurology

Dr. Igor Grant and the CHARTER Group have a featured article in the June 2014 issue of Neurology,  “Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline”.  Their study presents further evidence that HIV-associated neurocognitive disorders remain prevalent despite combination antiretroviral therapy.  The study demonstrates that early asymptomatic neurocognitive impairment (ANI) confers an increased risk and faster development of functional/symptomatic decline in individuals with HIV disease progression.  These findings highlight the importance of identifying those with ANI in the clinic early on to offer an opportunity to modify treatment to delay progression to symptomatic/functional decline.

Click Here for link to Pubmed - and full article when available in Pubmed Central.


CHARTER Longitudinal Neurocognitive Data Unveiled at AIDS 2014

Dr. Robert Heaton presents the longitudinal data from the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study at the 20th International AIDS Conference (AIDS 2014) being held from 20-25 July 2014 at the Melbourne Convention and Exhibition Centre, in Melbourne, Australia.

Key points of the presentation include that neurocognitive change (NC) change is common in HIV infection, there are clinical and biological predictors of NC change, that the increased comorbidity burden and factors associated with Hispanic ethnicity deserve more attention in clinical care of HIV+ individuals, and that consistent use of ART to maintain virologic control may protect the central nervous system and improve NC outcomes.

To Cite:

Heaton RK, Franklin DR, Deutsch R, Letendre SL, Ellis RJ, Blackstone K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelmen BB, McArthur JC, Morgello S, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Grant I, for the CHARTER Group.  (IP). Neurocognitive change in the era of HIV combination antiretroviral therapy: A longitudinal CHARTER Study. 20th International AIDS Conference



Dilip Jeste Appointed as First Associate Dean for Healthy Aging and Senior Care

Dr. Dilip V. Jeste, Distinguished Professor of Psychiatry and Neurosciences, has been appointed the first associate dean for Healthy Aging and Senior Care at UC San Diego and will direct the newly established Center on Healthy Aging and Senior Care

Dr. Jeste collaborates with HNRP investigators on research regarding aging and HIV infection. Examples of publications include:

Moore RC, Fazeli PL, Jeste DV, Moore DJ, Grant I, Woods SP.  (2014). Successful cognitive aging and health-related quality of life in younger and older adults infected with HIV. AIDS And Behavior, Epub. March 18. PMID: 24633788  

Moore RC, Moore DJ, Thompson WK, Vahia IV, Grant I, Jeste DV.  (2013). A case-controlled study of successful aging in older HIV-infected adults. The Journal of Clinical Psychiatry, 74(5), e417-23. PMID: 23759460  PMCID: PMC3683870 

Click Here to link to an article in The Oprah Magazine about stress where Dr. Jeste is one of the highlighted researchers.

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