Research Directions

HNRP ASSOCIATED STUDIES

HNRP associated studies primarily focus on understanding the effect of HIV and co-factors on the central nervous system (CNS).  Major themes include research into cognitive impairment, neurologic disorders, and antiretroviral issues (for example, understanding and optimizing CNS treatment, drug resistance, etc.), especially in the context of co-factors such as methamphetamine abuse and aging.

Descriptions of the major programs are below:

Translational Methamphetamine AIDS Research Center (TMARC)

tmarc logoThe Translational Methamphetamine AIDS Research Center (TMARC) is supported by public funding from the National Institutes of Health (NIH) and National Insititute on Drug Abuse (NIDA) (NIH/NIDA Award Number P50DA026306) to provide scientific leadership, technical support, and opportunities for training to coalesce the efforts of an interdisciplinary group of investigators to elucidate the combined effects of methamphetamine and HIV infection on the central nervous system.

California NeuroAIDS Tissue Network (CNTN)

cntn logoThe California NeuroAIDS Tissue Network (CNTN) is a research resource based at the University of California, San Diego, sponsored by the U.S. National Institute of Mental health (NIMH) and the National Institutes of Health (NIH) (NIMH/NIH Award Number U24 MH100928). CNTN acquires and makes available well-characterized tissues from individuals who have Central Nervous System involvement with Human Immunodeficiency Virus (HIV).

CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER)

charter logo

The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) study was funded in September 2002 in response to NIMH RFA 00-AI-0005 to explore the changing presentation of HIV neurological complications in the context of emerging antiviral treatments such as highly active antiretroviral therapy (HAART). CHARTER’s study aims are to determine how central and peripheral nervous system complications of HIV are affected by different histories and regimens of antiretroviral therapy (ART). Participants receive comprehensive neuromedical, neurocognitive, and laboratory examinations, with a subset undergoing host/viral genetic characterization and neuroimaging. In order to have a broad representation of participant characteristics, CHARTER was conducted at six performance sites nationally whose activities were coordinated by the University of California San Diego (UCSD), the principal grantee institution, which included several technical, scientific, and administrative cores to guide the work.

In September 2015, the CHARTER study resources, including specimens and data, were combined with the resources of the National NeuroAIDS Tissue Consortium (NNTC). The CHARTER database as well as data/specimen request management responsibilities were transferred to the NNTC Data Coordinating Center (DCC) while the physical specimens remain at UCSD. The DCC is a partnership between the University of Nebraska Medical Center (UNMC) and the Emmes Corporation, led by Dr. Howard Fox of UNMC. To access these resources please go to charternntc.org.

HIV Neurobehavioral Research Center (HNRC)

The mission of the HIV Neurobehavioral Research Center (HNRC) is to increase our understanding of how HIV and other diseases affect the human nervous system. The Center is supported by public funding from the National Institutes of Health (NIH) (NIMH Award Number P30MH062512). The HNRC conducts local, national, and international research devoted to advancing our knowledge of the prevention, diagnosis and treatment of HIV-related diseases as they affect the brain and nervous system, and result in impairment of everyday functioning.

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