Accomplishments and Research Directions

1. HNRC Scientific Themes
   1. What attributes of the virus, host, and host-virus interaction determine presentation of HIV-associated neurobehavioral disorders?
   2. What are the actual mechanisms by which the host-virus factors generate neural injury and neurobehavioral disorders?
   3. What is the role of co-pathogens and comorbidities in neuroAIDS?
   4. How can treatments be optimized to prevent or ameliorate neuroAIDS?
   5. What is the effect of HIV neurocognitive complications on everyday functioning; do treatments that correct neurocognitive abnormalities restore productivity and quality of life?
2. Selected Findings from HNRC-supported Projects (2000 - 2005)
   • Clinical Epidemiology of HIV
   • HIV Neuroadaptation and Neurovirulence
   • Host Genetics
   • Role of Co-factors
   • Effects of Treatment on Neurocognitive Function
   • Implications of Neurocognitive Impairment on Everyday Functioning
3. HNRC Contributions to Methods Development
4. The HNRC as a National and International Resource
5. Future Directions