CNS Penetration Effectiveness (CPE) Ranks 2010

Higher penetration scores equal greater penetration of the drug into the central nervous system (CNS).  For a more in depth discussion please review the following abstract:

Letendre SL, FitzSimons C, Ellis RJ, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Vaida F, Heaton R, Grant I, and the CHARTER Group.  (2010). Correlates of CSF Viral Loads in 1,221 volunteers of the CHARTER cohort. 17th Conference on Retroviruses and Opportunistic Infections.