The following were presentations/posters originating from HNRP research presented at the 2016 Annual Conference on Retroviruses and Opportunistic Infections taking place in Boston, Massachusetts from 2/22/16 – 2/25/16: 

de Oliveria MF, Chaillon A, Letendre S, Strain M, Ellis R, Morris S, Little S, Smith DM, Gianella S. (2016). Compartmentalized HIV DNA populations persist in CSF despite suppressive ART.

Evering T, St. Bernard L, Abolade J, Mohri H, Markowitz M. (2016). Relative frequency of drug resistance mutations on individual HIV-1 genomes in HAND. 

The Paul Satz Award recognizes Dr. Grant’s career contributions to the mentorship of doctoral students. In the award presentation it was noted that Dr. Grant has mentored 35 Ph.D.s and M.D.s, and served as the primary dissertation advisor to 23 of these as part of the UCSD/SDSU Joint Doctoral Program in Clinical Psychology.  The nominees were two former graduate students that Dr. Grant mentored, Sean Rourke, Ph.D., who is now Professor of Psychiatry at the University of Toronto and Jennifer Manly, Ph.D., Associate Professor of Neurology at Columbia University.

Recently published results from an HNRP HIV and Aging study reported that HIV infection significantly increased the risk of neurocognitive decline independent of age.  Approximately 16% of HIV+ persons regardless of age showed some cognitive decline with only about 3% of HIV- persons showing similar symptoms. The study supports the relevance of surveillance for neurocognitive decline in order to treat at an early stage.  This is important, as symptomatic cognitive decline has been linked to increased rates of depression and a reduced quality of life.

Sheppard DP, Woods SP, Bondi MW, Gilbert PE, Massman PJ, Doyle KL.  (2015). Does older age confer an increased risk of incident neurocognitive disorders among persons living with HIV disease? The Clinical Neuropsychologist, 29(5), 656-77. PMID: 26367342  PMCID: PMC4570033 

The following were posters originating from HNRP research presented at the International Neuropsychological Society's (INS) 44th Annual Meeting in Boston from 2/3/16 – 2/6/16: 

Babakhanyan I, McKenna B, Casaletto K, Heaton RK. NIH Tollbox Emotion Domain: Creation of census stratified normative data, summary scales and base rates for distressed emotional functioning.

Casaletto K, Moore D, Woods S, Heaton R. Metacognition is associated with executive dysfunction and manifest everyday functioning in HIV infection.

Doyle KL, Woods SP, Morgan EE, Cameron MV, and the HNRP Group. The effects of HIV-associated neurocognitive disorders across an integrated functional model of health literacy.

Doyle KL, Woods SP, McDonald C, Leyden K, Holden H, Morgan EE, Gilbert PE, and the HNRP Group. Verbal learning and memory profiles in HIV-associated neurocognitive disorders: A comparison with Huntington's Disease and Temporal Lobe Epilepsy.

Dr. Grant through his work as Director of the HIV Neurobehavioral Research Center Program (HNRP), which includes the California NeuroAIDS Tissue Network (CNTN), the Translational Methamphetamine AIDS Research Center (TMARC), the HIV Neurobehavioral Research Center (HNRC), the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) and the University of California Center for Medicinal Cannabis Research (CMCR), has contributed to a large body of research addressing HIV neurobiology, substance abuse and treatment-resistant depression.

Now that the UC San Diego Health has been designated a member of the National Network of Depression Centers (NNDC), a consortium working to accelerate research in these areas, he as chair of the Department of Psychiatry at the University of California, San Diego School of Medicine can more directly apply research to further treatment for individuals suffering from these maladies.

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