Current Research Projects - Blog Style
Current Research Projects - Blog Style
Mechanisms of Neuroprotection in HIV Encephalitis
Agency: NIH/NIMH
Agency Award Number: 5R01MH062962-08
To investigate the role of alterations in CDK5 signaling pathway in the molecular mechanisms of synapto-dendritic damage triggered by HIV proteins, and to determine the involvement of the CDK5 signaling pathway in the mechanisms of defective neurogenesis triggered by HIV proteins.
NeuroAIDS in Cameroon: Molecular Determinants
Agency: NIH/NIMH
Agency Award Number: 5R21MH080611-02
To investigate whether infections with HIV isolates that have a particular genetic characteristic makes patients more susceptible to neurocognitive disorders.
Creating a Pediatric Imaging-Genomics Data Resource
Agency: NIH/NIDA
Agency Award Number: 1RC2DA029475-01
To address the discrepancy between currently available imaging-genetics data in children of different ages and those available in adults.
Methamphetamine Abuse, Acute HIV Infection, GALT Destruction, and HIV Associated Neurocognitive Disorder (HAND)
Agency: NIH/NIDA
Agency Award Number: Suppl
To examine whether active METH use during the acute phase of HIV infection worsens the depletion of gut-associated lymphocyte tissue (GALT) and therefore increases the risk of micorbial translocation, inflammatory response, and neurocognitive impairment.
ARC: Biomarkers/NC Impairment
Agency: NIH/NIMH
Agency Award Number: Suppl
An administrative supplement to evaluate the relationship between biomarkers assessed in various fluids/compartments and the development of, or recovery from, HIV-associated neurocognitive disorders.
COMT Genotype and Risky Decision Making in HIV and Methamphetamine Dependence
Agency: NIH/NIDA
Agency Award Number: 1R01DA026334-01A1
To investigate the effects of COMT genotype on executive functioning, preexisting impulsive traits, measurable behaviors indicating impulsivity and novelty seeking, as well as decision-making choices, on HIV risk behaviors among individuals with METH dependence and/or HIV infection.
Multimodel Correlation of Imaging Markers and Neuropathogenesis of NeuroAIDS
Agency: NIH/NIMH
Agency Award Number: 5R01MH84756-012
To conduct a multi-parametric examination of neuropathogenetic phenomena that are induced by HIV infection, correlating markers of the disease revealed by different imaging modalities (in vivo and ex vivo) with those localized by specific histological methods to improve our understanding of HIV neuropathogenesis towards the earliest detection by non-invasive means of neurological signs and response to treatment.