Featured Publications

Featured Publications

Since 2000 the rates of primary and secondary syphilis infection in the US have been steadily increasing; if syphilis goes untreated the tertiary stage of infection can lead to central nervous system damage, resulting in neurosyphilis. Syphilis and HIV infection co-occur frequently. Neurosyphilis may increase HIV replication in the brain and spinal cord, possibly through immune activation that persists even after syphilis treatment.

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Performance on some mental rotation tasks (the ability to manipulate three-dimensional objects in space) is negatively impacted by HIV infection. Worse performance on mental rotation tasks is also associated with worse performance on measures of executive function and working memory. These findings suggest that HIV infection may disrupt the fronto-striato-parietal network within the brain.

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