Agency: NIH/NIMH/NINDS
Agency Award Number: HHSN271201000030C

Summary: To further utilize and expand datasets and specimens collected under current/previous NIMH CHARTER contracts to serve as a continuing resource to the broader NeuroAIDS research community to study the pathophysiology of HIV-Associated Neurocognitive Disorders.

Details

Written by Scott Letendre, M.D.

Agency: NIH/NIMH
Agency Award Number: R01MH092225

The project proposes to demonstrate that HAND can be prevented by using better penetrating antiretroviral therapy, which should influence HIV treatment guidelines in the U.S., China and elsewhere and ultimately lead to preservation of normal neurocognitive functioning in people afflicted with HIV/AIDS.

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Written by Eliezer Masliah, M.D.

Agency: NIA
Agency Award Number: R01AG043384

For this project we propose to better understand the mechanisms through which HIV proteins interfere with autophagy leading to protein accumulation and neurotoxicity, and to determine whether activation of the autophagy pathway is neuroprotective in preclinical models of HIV neurotoxicity and aging.

Details

Written by Ian Everall, M.D., Ph.D.

Agency: NIH/NIDA
Agency Award Number: R21DA027273

To investigate the relationship between the inherited genotype of catechol-o-methyl transferase (COMT) and the protection against the development of HIV related impaired executive function, which is lost when methamphetamine (METH) is used by the affected individuals.